AIDS has challenged many concepts and practices within nursing. Because of the serious implications attending a positive diagnosis, and because patients with AIDS have become articulate and well informed, familiar principles have been exposed to renewed scrutiny. Anomalies and dilemmas have been revealed. Results from a recent Institute of Medical Ethics survey carried out by the author have illustrated some of the theoretical concepts. Confidentiality has assumed new dimensions. Partnership and mutual empowerment are seen as keys to sound practice involving (...) the patient in decision-making. A vital ingredient relates to the preparation of professionals; they need to be aware of those attitudes and prejudices within themselves which potentially stand in the way of caring well. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Notes and Fragments SARTRE AND SEXISM by Hazel E. Barnes Insofar as is possible, I want to consider here not Sartre the man but Sartre the philosopher—or, more precisely, the philosophy of Sartre. To askwhether Sartre's long association with Simone de Beauvoir was a model of human relations at their best or an example ofbad faith on both sides is not to my present purpose. Nor are his (...) numerous, sometimes rather unsavory affairs with other women. Of course, the man and his work cannot be separated entirely. Sartre himselfadmitted that despite his wholehearted support of women's liberation, there remained in him vestiges of ingrained male chauvinism which he found difficult to eradicate.1 We should expect to find echoes of these in his writing, and we do—not in the ideas but in the imagery and rhetoric, and these not only in the fiction but in the philosophical works. The grossest example is the well-known passage in which Sartre discusses the "existential meanings" ofslime and holes.2 Slime, the great "Antivalue," is "a moist and feminine sucking" and "a sickly-sweet feminine revenge." Moreover—and this is even worse—Sartre allows his meditation on holes to lead by a process of his own associations to the idea ofa woman's sex as "a voracious mouth" evoking the male castration complex. This is not the only place where Sartre links female with notions of a treacherous receptivity. Furthermore, such passages are complemented by others where Sartre employs male sexual imagery to describe the activity of consciousness. Knowledge is portrayed as penetration and conquest. He points out, without objecting, that banal metaphors of everyday language suggest that "knowing" has overtones of carnal knowing and sexual violation: "What is seen is possessed; to see is to deflower.... The unknown object is given as immaculate, as Philosophy and Literature, © 1990, 14: 340-347 Hazel E. Barnes341 virgin, comparable to a whiteness.... Man has not yet 'snatched' its secret away from it.... Figures of speech... like that of the 'unviolated depths of nature' suggest the idea ofsexual intercourse more plainly."3 There can be no doubt that a full investigation ofthe linguistic codes in Sartre's writing would reveal him to be a man comfortably ensconced in a world of male dominance. Yet Collins and Pierce in their excellent article, "Holes and Slime: Sexism in Sartre's Psychoanalysis," even as diey deplore Sartre's sexist language and his failure to depict any fictional female characters as embodiments of existential authenticity, admit that these weaknesses are at variance with the central philosophy ofBeing and Nothingness and not derived logically from it.4 I agree, and diat is why I hold that the sexism is there but is contingent, relevant to our appraisal of die writer but not essential to ourjudgment on the philosophy and its potential value as a support to feminism. In saying this I am partially making the sort of distinction employed by Jean Grimshaw, who points out that a philosophy built on male assumptions may exclude women essentially as with Kant, inconsistendy as with Aristode, or inadvertendy as with Descartes.5 The difference with Sartre is that in spite of the occasional lapse into traditional male linguistic tropes, the work, like its author, is notjust theoretically egalitarian but concerned explicidy with forms of oppression and the problems of disfavored groups. More than that of any other male writer, Sartre's philosophy seems to me to demand feminism as one of its natural consequences. That diis has been historically true is shown, ofcourse, by the fact that Simone de Beauvoir used Sartrean existentialism as the foundation for her own original analysis of women's situation in TL· Second Sex. The irony is diat this book, which played a key role in launching the movement for women's liberation throughout the world, has been adversely criticized by later feminists precisely on the grounds of its Sartrean orientation, along with Beauvoir's emphasis on women's right to share the things men value rather than to challenge those values. Beauvoir herself later recognized that the book did not go far enough, but she never renounced what she had written there. My claim... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Hazel E. Barnes BEAUVOIR AND SARTRE: THE FORMS OF FAREWELL There ARE MANY forms of farewell. The formal interview may be one of them, an autobiography another, the biography written by a relative or close friend of the deceased a third. In The Words Sartre bade farewell to his childhood. He thought he was saying goodbye to literature at the same time, though this adieu turned out to (...) be more in the nature of au revoir or even à bientôt. In an extended interview on the occasion of his seventieth birthday and in a three-hour documentary film, Sartre commented on the events ofhis life, his writings, his hopes and aspirations, his political judgments. Each of these was a summing up, and a selfappraisal, a final statement, too, inasmuch as Sartre's ill health and near blindness made it clear to him that he would not be writing anymore. Simone de Beauvoir obviously drew up some kind of final reckoning in the last volume of her autobiography, Tout comptefait {Account Closed). All of these are farewells of a sort, official valedictories. They have been much discussed, and I will not dwell on them here. Two other works bearing Beauvoir^ name are farewells in a different sense. They are preparations for leave-taking and records of remembrance for the bereaved. They have been combined in a volume published in late 1981, a year and a half after Sartre's death. The first of these is La Cérémonie des adieux (The Ceremony ofFarewells).? This is an account of the decade preceding Sartre's death. The title is itself a recollection of a poignant moment, as Beauvoir explains: "Then this is the ceremony of farewells!' Sartre said to me as we were leaving each other for a month at the beginning of one summer. I had a presentiment of the meaning these words would one day assume. The ceremony lasted ten years. It is these ten years that I recount in this book." The record is annalistic, the same kind of detailed year-by-year account of events and her reactions to them 21 22Philosophy and Literature mat Beauvoir employed in the first three volumes of her autobiography. But there her stated intention was to keep herselfas the center offocus and to speak of Sartre only insofar as his existence was intertwined with her own. In the preface to The Ceremony of Farewells she states that she has recorded these ten years as she had lived them, but that the book is devoted wholly to Sartre. Ifshe has spoken also ofherself, it is because "the witness is a part of what he witnesses." The book is dedicated "To those who loved Sartre, love him, will love him." Indeed, it has been written for them by one who is of them. The second work is Entretiens avecJean-Paul Sartre, a collection of interviews she herself conducted with Sartre in the summer of 1974. These have been subjected to superficial editing but by no means reworked into literature. Beauvoir wanted to give to readers the opportunity "to follow the meanders of his thought and to hear his living voice." Here she uses the method adopted in the fourth volume ofher autobiography, where she grouped her reminiscences by topics. Sartre responds at length to her questions on a vast variety ofsubjects, ranging from food likes and dislikes to his changing concepts of freedom, from sexual preferences to politics; there are comments on schoolboy fights with Merleau-Ponty, and later arguments with Camus, thoughts on literature, on death, on God. A reviewer has remarked that these interviews represent "a worthwhile approximation to the autobiography [Sartre] never wrote."2 Thus we have a work that falls in between biography and autobiography, because of the author's close involvement with her subject, and we have a set of autobiographical interviews. In both Beauvoir is recorder and commentator, Sartre central subject and actor. The two may serve for mutual corroboration and correction. Together diey express Beauvoir^ and Sartre's farewell to each other and his farewell to life. I will begin with the Interviews and focus my discussion on a few selected items which seem to me especially... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Hazel E. Barnes FLAUBERT AND SARTRE ON MADNESS IN KING LEAR T'oward the end of the second volume of The Family Idiot (L'Idiot de la famille), in a section called "Exercises and Reading," Sartre discusses Flaubert's reading of Shakespeare.1 In the context Sartre describes how Flaubert spent his time during one of the rare periods when he was not even attempting to write anything; more than two years (...) elapsed between the completion of the first Sentimental Education in January 1845 and die beginning of his collaboration widi Maxime Du Camp on La Bretagne. Along with doing desultory background reading for "an oriental tale," and analyzing the plays ofVoltaire, Flaubert claimed to be studying the Greek and Roman authors and a selected few of the later "great immortals." Sartre shows that Flaubert's way of reading them was entirely different from the critical analysis which he directed on the work of his contemporaries. Essentially it was a series of"rereadings," and its purpose was not to gain knowledge or even a fuller understanding of the text. In a letter to Mlle de Chantepie, Flaubert counsels her to take one of the great writers and "study him in depth," reading from beginning to end and then starting over again: "But do not read, as children read, to amuse yourself, nor as the ambitious read, to instruct yourself. No, read so as to live. Create in your soul an intellectual atmosphere which will be compounded from the emanation of all the great minds."2 How can Flaubert both counsel his correspondent to study in depdi and not to seek instruction? The kind ofstudy he has in mind, Sartre claims, is comparable to the way in which an amateur pianist might "study" Chopin, where die aim is not to understand analytically but to perfect a particular interpretation and to evoke a certain aesdietic reaction. Flaubert resists instruction because new knowledge risks forcing change. What he wants is 211 2 1 2 Philosophy and Literature to rediscover the same eternal truths and emotions.3 It is also to find inspiration for his own dreams, an oneiric reading. In this connection Sartre makes two important points. First, in striving to cultivate for the soul "an intellectual atmosphere... compounded from the emanation of all the great minds," the artist is adding so many strings to his lyre — the laugh of Rabelais, the cosmic passions of Shakespeare, the skepticism of Montaigne. This is whyJules at the end of die first Sentimental Education plans to study die great writers, beginning with Homer — not to learn dieir technique but to enlarge the artist's sensibility. Sartre's second point is made apropos of Flaubert's rereading of Shakespeare. Flaubert fluctuates between two responses. Sometimes he is depressed at the thought of his own lack of genius in comparison with Shakespeare. "That good man will drive me mad.... All odiers seem to me children beside him."* At odier times he experiences what Sartre calls a "glorifying identification." It is as though in imagination he becomes Shakespeare. In part this is because, as he writes in this same letter, we artists "breathe in our existence by means of die sentence." Sartre notes that for Flaubert the existence in question is a literary reality, not that of die everyday world; we may breathe it in either dirough writing or through reading. At this particular moment in his life, Sartre argues, Flaubert's program of study was in bad faith. He allowed die imaginary identification to suffice. Sartre goes so far as to say, "He reads in order not to write; in diis masturbatory substitute for the act, he makes himself an aumor all at once, under anodier name, in order not to work at becoming the writer of genius he wants to be." This comment makes sense if we recall Flaubert's situation in 1845-47. After the nervous crisis at Pont-L'Evêque he knew that either he would be a writer or he would remain a feeble invalid, an object of pity, the "family idiot." "There he is, dien, paralyzed by two opposing forces: hope and die fear of being disappointed " (p. 2021). No wonder he... (shrink)

While Sartre scholars cannot fairly be described as being opposed to science, they have, for the most part, stayed aloof. The field of psychology, of course, has been an exception. Sartre himself felt compelled to present his own existential psychoanalysis by marking the parallels and differences between his position and traditional approaches, particularly the Freudian. The same is true with respect to his concept of bad faith and of emotional behavior. Scholars have followed his lead with richly productive results. But (...) we may note that the debate has centered on psychic and therapeutic issues, aspects of what Sartre called le vécu or lived experience, rather than on the findings of cognitive science or neuroscience. Although all existentialists and phenomenologists accept as a central tenet the fact that consciousness is embodied, there has been virtually no concern with the biological substratum. But the study of consciousness cannot be restricted within its own narrow confines—unlike, say, Greek grammar, which can be learned without reference to the rules of Arabic. At some point, there must be established an organic foundation for the behavior of the conscious organism. (shrink)

Ubiquitination is essential in mediating diverse cellular functions including protein degradation and trafficking. Ubiquitin‐protein (E3) ligases determine the substrate specificity of the ubiquitination process. The Nedd4 family of E3 ligases is an evolutionarily conserved family of proteins required for the ubiquitination of a large number of cellular targets. As a result, this family regulates a wide variety of cellular processes including transcription, stability and trafficking of plasma membrane proteins, and the degradation of misfolded proteins. The modular architecture of the proteins, (...) comprising a C2 domain, multiple WW domains and a catalytic domain, enables diverse intermolecular interactions and recruitment to various subcellular locations. The WW domains commonly mediate interaction with substrate proteins; however, an increasing number of Nedd4 targets do not contain obvious WW domain‐interaction motifs suggesting the involvement of accessory proteins. This review discusses recent insights into how accessory and adaptor proteins modulate the activities of Nedd4 family members, including recruitment of novel substrates, alteration of subcellular localisation and effects on ubiquitination. BioEssays 28: 617–628, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

The ethical issues around decision making on behalf of infants have been illuminated by two empirical research studies carried out in Scotland. In-depth interviews with 176 medical and nursing staff and with 108 parents of babies for whom there was discussion of treatment withholding/withdrawal, generated a wealth of data on both the decision making process and the management of cases. Both staff and parents believe that parents should be involved in treatment limitation decisions on behalf of their babies. However, whilst (...) many doctors and nurses consider the ultimate responsibility too great for families to carry, the majority of parents wish to be the final arbiters. We offer explanations for the differences in perception found in the two groups. The results of these empirical studies provide both aids to ethical reflection and guidance for clinicians dealing with these vulnerable families. They demonstrate the value of empirical data in the philosophical debate. (shrink)

Representatives from eight European countries compared the legal, ethical and professional settings within which decision making for neonates takes place. When it comes to limiting treatment there is general agreement across all countries that overly aggressive treatment is to be discouraged. Nevertheless, strong emphasis has been placed on the need for compassionate care even where cure is not possible. Where a child will die irrespective of medical intervention, there is widespread acceptance of the practice of limiting aggressive treatment or alleviating (...) suffering even if death may be hastened as a result. Where the infant could be saved but the future outlook is bleak there is more debate, but only two countries have tested the courts with such cases. When it comes to the active intentional ending of life, the legal position is standard across Europe; it is prohibited. However, recognising those intractable situations where death may be lingering and unpleasant, Dutch paediatricians have reported that they do sometimes assist babies to die with parental consent. Two cases have been tried through the courts and recent official recommendations have set out standards by which such actions may be assessed. (shrink)

Dilemmas about resuscitation and life-prolonging treatment for severely compromised infants have become increasingly complex as skills in neonatal care have developed. Quality of life and resource issues necessarily influence management. Our Institute of Medical Ethics working party, on whose behalf this paper is written, recognises that the ultimate responsibility for the final decision rests with the doctor in clinical charge of the infant. However, we advocate a team approach to decision-making, emphasising the important role of parents and nurses in the (...) process. Assessing the relative burdens and benefits can be troubling, but doctors and parents need to retain a measure of discretion; legislation which would determine action in all cases is inappropriate. Caution should be exercised in involving committees in decision-making and, where they exist, their remit should remain to advise rather than to decide. Support for families who bear the consequences of their decisions is often inadequate, and facilitating access to such services is part of the wider responsibilities of the intensive care team. The authors believe that allowing death by withholding or withdrawing treatment is legitimate, where those closely involved in the care of the infant together deem the burdens to be unacceptable without compensating benefits for the infant. As part of the process accurate and careful recording is essential. (shrink)

Grapheme-colour synaesthesia is a perceptual experience where graphemes, letters or words evoke a specific colour, which are experienced either as spatially coincident with the grapheme inducer (projector sub-type) or elsewhere, perhaps without a definite spatial location (associator sub-type). Here, we address the question of whether synaesthesia can be rapidly produced using a hypnotic colour suggestion to examine the possibility of ‘hypnotic synaesthesia’, i.e. subjectively experienced colour hallucinations similar to those experienced by projector synaesthetes. We assess the efficacy of this intervention (...) using an “embedded figures” test, in which participants are required to detect a shape (e.g., a square) composed of local graphemic elements. For grapheme-colour synaesthetes, better performance on the task has been linked to a higher proportion of graphemes perceived as coloured. We found no performance benefits on this test when using a hypnotic suggestion, as compared to a no-suggestion control condition. The same result was found when participants were separated according to the degree to which they were susceptible to the suggestion (number of coloured trials perceived). However, we found a relationship between accuracy and subjective reports of colour in those participants who reported a large proportion of coloured trials: trials in which the embedded figure was accurately recognised (relative to trials in which it was not) were associated with reports of more intense colours occupying a greater spatial extent. Collectively, this implies that hypnotic colour was only perceived after shape detection rather than aiding in shape detection via colour-based perceptual grouping. The results suggest that hypnotically induced colours are not directly comparable to synaesthetic ones. (shrink)

We tested the hypothesis that “good feelings”—the central element of subjective well-being—are associated with interdependence and interpersonal engagement of the self in Japan, but with independence and interpersonal disengagement of the self in the United States. Japanese and American college students (total N = 913) reported how frequently they experienced various emotional states in daily life. In support of the hypothesis, the reported frequency of general positive emotions (e.g. calm, elated) was most closely associated with the reported frequency of interpersonally (...) engaged positive emotions (e.g. friendly feelings) in Japan, but with the reported frequency of interpersonally disengaged positive emotions (e.g. pride) in the United States. Further, for Americans the reported frequency of experience was considerably higher for positive emotions than for negative emotions, but for Japanese it was higher for engaged emotions than for disengaged emotions. Implications for cultural constructions of emotion in general and subjective well-being in particular are discussed. (shrink)

In his two articles, F. P. A. Demeterio III attempts to classify works in Filipino philosophy using a list of twelve (or sixteen) supposed discourses that prominent philosophers in the Philippines have engaged in and published over the past few years. From this list, he advises current Filipino philosophers to invest their time and effort in contributing to only five of these because of their alleged higher measure of "developmental potential" as opposed to other discourses. In this paper, we raise (...) some fundamental issues with Demeterio's approach. We show that (i) his work's conclusions rest on questionable methodological assumptions that make (ii) the discourses which the work arrived at and the rankings in terms of "developmental potential" superficial and ungrounded. Finally, (iii) instead of fulfilling the main aim of advancing research in Filipino philosophy, the proposed approach may actually lead to its stagnation and demise. We argue that these issues, if left unanswered, make Demeterio's whole approach to Filipino philosophy unsound and may put into question the employment of such an approach. (shrink)

The British Government has recently agreed proposals for a National Numeracy Strategy which claims to be based on evidence concerning 'what works'. This article reviews the literature in each key area in which recommendations are made, and makes a judgement of whether the claim is justified. In some areas (e.g. calculators) the recommendations run counter to the evidence.

Many writers in various fields--philosophy, religion, literature, and psychology--believe that the question of the meaning of life is one of the most significant problems that an individual faces. In The Meaning of Life, Second Edition, E.D. Klemke collects some of the best writings on this topic, primarily works by philosophers but also selections from literary figures and religious thinkers. The twenty-seven cogent, readable essays are organized around three different perspectives on the meaning of life. In Part I, the readings assert (...) and defend the theistic view that without the existence of God--or faith in God--life has no significance or purpose. In Part II the selections deny this thesis, defending instead the humanistic alternative--that life has or can have meaning and worth without any theistic beliefs or commitment. In the final group of readings, contributors ask if the question of the meaning of life is in itself legitimate and significant. The volume also includes an introduction by the editor and a selected bibliography. This new edition adds essays by A. J. Ayer, Hazel Barnes, William Lane Craig, Owen Flanagan, Antony Flew, Thomas Nagel, Kai Nielsen, Philip L. Quinn, Arthur Schopenhauer, and Walter T. Stace.The only anthology of its kind, The Meaning of Life, Second Edition, is ideal for courses in introduction to philosophy and human nature. It also provides an accessible and stimulating introduction to the subject for general readers. (shrink)